中国真菌学杂志

目的调查住院患者光滑念珠菌检出的特征。方法回顾性调查分析白求恩国际和平医院2008年1月～2009年4月住院患者中光滑念珠菌检出阳性者的临床资料,以同期白念珠菌检出患者为对照。结果其间共有52例详细病史资料记录的光滑念珠菌检出患者,以60岁以上老年人为主,占65.4%;主要分离自痰标本,占76.9%。患者患有多种基础疾病,以肺部感染(28例,53.8%)、恶性肿瘤(20例,38.5%)、脑梗死(15例,28.8%)常见。使用抗生素(52例,100%)、留置导尿管(15例,28.8%)是光滑念珠菌检出者的主要实施医疗措施。氟康唑是临床最常用的治疗光滑念珠菌感染药物(23例,44.2%)。光滑念珠菌检出患者死亡率高(14例,26.9%),高于同期白念珠菌检出对照组(6.2%,P=0.004)。结论光滑念珠菌检出患者与白念珠菌检出具有相似的临床流行病学特征。

Objective To describe the characteristics of Candida glabrata isolated from inpatients.Methods Medical records of inpatients with Candid glabrata during January 2008 to April 2009 from Bethun Internationnal Peace Hospital were retrospectively analyzed and compared to those of the inpatients with Candida albicans at the same periods as control.Results In the study periods,about 65.4% of totally 52 patients with detailed medical records these patients were elder over 60-year,and 76.9% of Candida glabrata were isolated from sputum.Most of these inpatients had multiple underlying diseases,including pulmonary infections(53.8%),malignant tumors(38.5%),and ischemic stroke(28.8%).The commonest predisposing factors were antibiotic therapy(100%)and indwelling urinary catheter(28.8%)were main risk factor.Fluconazole was considered as the most common drug(44.2%)for treatment.Mortality in our patients with Candida glabrata(26.9%)was more higher than that with Candida albicans(6.2%,P=0.004).Conclusions Patients with Candida glabrata had similar epidemiological features to Candida albicans.